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U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure-activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.

U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference), and U-69,593, which share very similar structures. Although not used medically, selective kappa ligands are used in research. Buy U-47700 Online.

U-47700 is an analgesic of the opioid family first developed by Upjohn some 40 years ago. It was derived from a related opioid, AH-7921. Despite its importance in developing this class of opioid chemicals, U-47700 has never itself been formally tested on humans or animals.

Pharmacology:
U-47700 is highly selective for the µ-opioid receptor and is believed to be roughly 7 to 8 times as powerful as morphine dose-per-dose. It is believed to be a strong kappa agonist, so should not produce substantial degrees of dysphoria or other unwanted effects.

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