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Gamma-Hydroxybutyric acid or γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at the GABAB receptor.

GHB has been used in a medical setting as a general anesthetic and as a treatment for cataplexy, narcolepsy, and alcoholism. It is also used illegally as an intoxicant, as an athletic performance enhancer, as a date rape drug, and as a recreational drug. It is commonly used in the form of a salt, such as sodium γ-hydroxybutyrate (Na.GHB, sodium oxybate, or Xyrem) or potassium γ-hydroxybutyrate (K.GHB, potassium oxybate). GHB is also produced as a result of fermentation and is found in small quantities in some beers and wines, beef, and small citrus fruits.

GHB has been used as a club drug, apparently starting in the 1990s, as small doses of GHB can act as a euphoriant and are believed to be aphrodisiac. GHB slang terms are liquid ecstasy, lollipops, liquid X, or liquid E due to its tendency to produce euphoria and sociability and its use in the dance party scene.

GHB became known to the general public as a date rape drug by the late 1990s. GHB is colorless and odorless and has been described as “very easy to add to drinks”. When consumed, the victim will quickly feel groggy and sleepy and may become unconscious. Upon recovery, they may have an impaired ability to recall events that have occurred during the period of intoxication. In these situations, evidence and the identification of the perpetrator of the rape are often difficult.

It is also difficult to establish how often GHB is used to facilitate rape as it is difficult to detect in a urine sample after a day, and many victims may only recall the rape sometime after its occurrence; however, a 2006 study suggested that there was “no evidence to suggest widespread date rape drug use” in the UK and that less than 2% of cases involved GHB, while 17% involved cocaine, and a survey in the Netherlands published in 2010 found that the proportion of drug-related rape where GHB was used appeared to be greatly overestimated by the media.

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The only common medical uses for GHB today are in the treatment of narcolepsy.

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