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Dextroamphetamine is a central nervous system (CNS) stimulant and an amphetamine enantiomer[note 2] that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. Dextroamphetamine was also used by military air, tank, and special forces as a ‘go-pill’ during fatigue-inducing missions such as night-time bombing missions or extended combat operations.

Uses

This combination medication is used to treat attention deficit hyperactivity disorder – ADHD. It works by changing the amounts of certain natural substances in the brain. Amphetamine/dextroamphetamine belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve your listening skills. This makes it one of the most commonly abused pharmaceutical drugs in the U.S.

Side Effects

Dexedrine and Adderall typically share the same side effects, warnings, and risks because they contain forms of the same drug.
Adderall and Dexedrine can also cause more serious side effects, especially when misused. Without proper medical care, side effects associated with prescription stimulant use can become life-threatening.

Differences between Dexedrine and Adderall

Dexedrine and Adderall both contain forms of the synthetic compound amphetamine, which is a central nervous stimulant.

Researchers still do not know exactly how amphetamine works. However, it seems to increase the release or effectiveness of certain neurotransmitters, the body’s chemical messengers, including:

dopamine
norepinephrine
serotonin
There are two active forms of the synthetic compound amphetamine: Dextro(d)-amphetamine and Levo(l)-amphetamine. Of the two forms, d-amphetamine is considered the stronger of the pair.

While the two forms of amphetamine differ in their makeup, both have proven effective for the treatment of ADHD since the 1970s.

Dexedrine contains the active ingredient d-amphetamine, while Adderall contains a 3:1 mixture Trusted Source of immediate-release d-amphetamine and l-amphetamine. Extended-release formulas of Adderall, such as Adderall XR, generally contain equal measures of immediate-release and delayed-release d-amphetamine and l-amphetamine.

Dexedrine is also available in a sustained-release formula (Dexedrine Spansule), containing time-release d-amphetamine.

Currently, immediate-release types of Dexedrine and Adderall are both approved by the U.S. Food and Drug Administration (FDA) for the treatment of ADHD in children aged 3 and older.

The extended-release types Dexedrine Spansule and Adderall XR are not approved for use in children under the age of 6. Dexedrine Spansule is also not approved for use in individuals over the age of 16.

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